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. 2024 Feb 12;67(4):2305–2320. doi: 10.1021/acs.jmedchem.3c02239

Table 1. List of All Racemic NMEs Approved by The FDA from 2013 to 2022.

year approved medicine name active substance therapeutic area indication/use no. stereocenters
2013 Pomalyst pomalidomide cancer multiple myeloma 1
2015 Zurampic lesinurad rheumatology gout 0a
2015 Farydak panobinostat lactate cancer multiple myeloma 1b
2015 Cresemba isavuconazonium sulfate infections aspergillosis 3c
2018 Diacomit stiripentol neurology anticonvulsant 1
2018 Krintafel tafenoquine infection malaria 1
2020 Barhemsys amisulpride gastroenterology nausea and vomiting 1
2020 Lampit nifurtimox infection Chagas disease 1
2021 Qelbree viloxazine psychiatry ADHD 1
2022 Elucirem gadopiclenol diagnostic imaging detection and visualization of lesions 6d
a

Lesinurad displays axial chirality.

b

The stereocenter is located on the lactate counterion.

c

One of the three stereocenters of isavuconazonium sulfate is undefined. It is marketed as a mixture of epimers.

d

The stereochemistry of all six stereocenters of gadopiclenol is undefined. It is marketed as a mixture of diastereomers.