Table 1. List of All Racemic NMEs Approved by The FDA from 2013 to 2022.
year approved | medicine name | active substance | therapeutic area | indication/use | no. stereocenters |
---|---|---|---|---|---|
2013 | Pomalyst | pomalidomide | cancer | multiple myeloma | 1 |
2015 | Zurampic | lesinurad | rheumatology | gout | 0a |
2015 | Farydak | panobinostat lactate | cancer | multiple myeloma | 1b |
2015 | Cresemba | isavuconazonium sulfate | infections | aspergillosis | 3c |
2018 | Diacomit | stiripentol | neurology | anticonvulsant | 1 |
2018 | Krintafel | tafenoquine | infection | malaria | 1 |
2020 | Barhemsys | amisulpride | gastroenterology | nausea and vomiting | 1 |
2020 | Lampit | nifurtimox | infection | Chagas disease | 1 |
2021 | Qelbree | viloxazine | psychiatry | ADHD | 1 |
2022 | Elucirem | gadopiclenol | diagnostic imaging | detection and visualization of lesions | 6d |
Lesinurad displays axial chirality.
The stereocenter is located on the lactate counterion.
One of the three stereocenters of isavuconazonium sulfate is undefined. It is marketed as a mixture of epimers.
The stereochemistry of all six stereocenters of gadopiclenol is undefined. It is marketed as a mixture of diastereomers.