Table 4.

Alpha diversity analysis of the gut microbiota

	Observed species	Chao1	Shannon	Simpson
At baseline
Placebo	822	405.3	6.614	0.902
Test group	810	420.7	6.098	0.908
p value	0.596	0.906	0.456	0.480
At 1 year
Placebo	806	411	6.516	0.888
Test group	863	443	7.392	0.989
p value	0.289	0.814	0.025	0.009