Table 5.

Drug safety assessment of metformin

	Test group	Placebo	p value
Creatinine (mg/dL)
At baseline	72.92	67.73	0.126
At 1 year	72.5	69.22	0.352
p value (baseline vs. 1 year)	0.913	0.378
Blood urea nitrogen (mg/dL)
At baseline	3.39	4.92	0.02
At 1 year	3.73	5.42	0.006
p value (baseline vs. 1 year)	0.229	0.575
Total cholesterol (mg/dL)
At baseline	3.75	2.93	0.112
At 1 year	3.74	2.62	0.023
p value (baseline vs. 1 year)	0.978	0.66
LDL cholesterol (mg/dL)
At baseline	2.06	2.26	0.768
At 1 year	2.21	2.34	0.988
p value (baseline vs1 year)	0.757	0.735
Aspartate aminotransferase (AST)
At baseline	19.6	14.85	0.045
At 1 year	17.4	15.22	0.061
p value (baseline vs. 1 year)	0.377	0.886
Alanine aminotransferase (ALT)
At baseline	33.19	15.02	0.089
At 1 year	18.29	16.47	0.336
p value (baseline vs. 1 year)	0.008	0.395
HbA1c (%)
At baseline	5.53	5.45	0.494
At 1 year	5.49	5.55	0.558
p value (baseline vs. 1 year)	0.665	0.412
HOMA-IR
At baseline	1.18	0.97	0.528
At 1 year	1.16	0.93	0.335
p value (baseline vs. 1 year)	0.968	0.826
BMI (Kg/m2)
At baseline	23.10	21.7	0.491
At 1 year	22.16	21.57	0.745
p value (baseline vs. 1 year)	0.543	0.956

Data are mean (SD). HOMA = fasting blood × glucose fasting insulin/22.5