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Standard Procedure (SP) dosing regimen.
| Standard Procedure | Buprenorphine | XR-NTX | PRN Adjunctive Medications |
|---|---|---|---|
| Days 1–5 | Dosing taper | – | X |
| Days 6–13 | – | – | X |
| Day 14 | − | 380 mg IM | X |
X = as needed adjunctive medications. Buprenorphine taper dosing varied based on sites’ clinical practices. An example buprenorphine taper was 8 mg on Day 1, 6 mg on Day 2, 4 mg on Day 3, 2 mg on Day 4, and 1 mg on Day 5.
