Table 3.

Rapid Procedure (RP) dosing regimen.

Rapid Procedure	Buprenorphine	1st NTX dose	2nd NTX dose	XR-NTX	Adjunctive Medications
Day 1	2–10 mg	–	–	–	X
Day 2	–	–	–	–	X
Day 3	–	0.5 mg	0.5 mg	–	X
Day 4	–	1 mg	1 mg	–	X
Day 5	–	3 mg	3 mg	–	X
Day 6	−	6 mg	–	380 mg IM	X

X = scheduled adjunctive medications. Scheduled adjunctive medications included: clonidine 0.1–0.2 mg every four hours (with hold parameters for systolic blood pressure < 90 mmHg, or heart rate < 60 beats per minute), clonazepam 1 mg every six hours (with hold for oversedation), antinausea medication daily (prochlorperazine 10 mg or ondansetron 8 mg), sleep aid at bedtime (zolpidem 5–10 mg, trazodone 50–100 mg, or other sleep aids), and nicotine replacement therapy (patch and gum) if tobacco use. Additional doses of adjunctive medications could be given as needed and included antiemetics, sleep aids, and acetaminophen or ibuprofen.