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. 2024 Feb 26;8(2):e50. doi: 10.1002/hem3.50

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© 2024 The Authors. HemaSphere published by John Wiley & Sons Ltd on behalf of European Hematology Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Immunoglobulin repertoires of follicular lymphoma (FL) and reactive B‐cells. (A) Clustering of Ig and T‐cell immunoglobulin repertoires (TCR) CDR3 sequences in a representative FL sample (UPN001). (B, D) Distribution of the lengths of the immunoglobulin heavy (IgH) (B) and immunoglobulin light (IgL) (D) CDR3 sequences. (C, E) Distributions of the percentages of homology of the IgHV and igLV sequences to their closest germlines. Red: dominant CDR3 sequences. Yellow: IgG/A and E reactive sequences. Blue: IgM reactive sequences. Purple: reactive Kappa light chain sequences. White: reactive Lambda light chain sequences.