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Estimated incidence of cardiovascular adverse events associated with immune checkpoint inhibitor therapy based on a safety meta-analysis (35, 36).
| Cardiovascular Adverse Event | Summary Incidence (95% CI) |
|---|---|
| Myocarditis | 0.3% (0.2 – 0.5%) |
| Pericarditis | 0.8% (0.6 – 1.1%) |
| Arrhythmias | 1% |
| Heart Failure | 0.9% (0.7 – 1.1%) |
| Myocardial Infarction | 0.7% (0.6 – 0.9%) |
| Ischemic Stroke | 0.9% (0.7% – 1.1%) |
| Venous Thromboembolism | 12.9% |
| Dyslipidemia | 1.9% (0.7 – 5.4%) |
