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Two-year cumulative incidence of cardiac adverse events in patients with primary NSCLC cancer treated with crizotinib (49).
| Cardiac Adverse Event | Population | Cumulative incidence rates (95% CI), % |
|---|---|---|
| Bradycardia | EU | 1.1 (0.0-3.0) |
| USA | 16.9 (10.5-24.7) | |
| QT interval prolongation related events | EU | 1.0 (0.0-3.1) |
| USA | 26.8 (17.6 - 36.9) | |
| Cardiac failure | EU | 0.5 (0.0 – 2.1) |
| USA | 6.8 (3.4 – 11.7) |
