Table 3.
Performance assessment on the estimated hazard ratios when the actual median survival times in treatment A is 91 days, and the actual median survival time in treatment B is 1.1–2 times longer than the actual median survival time in treatment A, based on simulations = 2000, censoring rate = 0.3.
EMEAN | ESE | ECP | EBIAS | RBIAS | MSE | POWER | ||||
---|---|---|---|---|---|---|---|---|---|---|
91 | 1.1 | 42 | 56 | 0.864 | 0.124 | 0.921 | −0.054 | −0.059 | 0.018 | 0.205 |
70 | 0.831 | 0.121 | 0.878 | −0.087 | −0.095 | 0.022 | 0.286 | |||
84 | 0.779 | 0.112 | 0.768 | −0.139 | −0.151 | 0.032 | 0.453 | |||
91 | 1.2 | 42 | 56 | 0.795 | 0.115 | 0.922 | −0.046 | −0.055 | 0.015 | 0.389 |
70 | 0.766 | 0.113 | 0.874 | −0.075 | −0.089 | 0.018 | 0.485 | |||
84 | 0.722 | 0.104 | 0.781 | −0.119 | −0.142 | 0.025 | 0.659 | |||
91 | 1.3 | 42 | 56 | 0.738 | 0.107 | 0.920 | −0.039 | −0.050 | 0.013 | 0.586 |
70 | 0.711 | 0.104 | 0.885 | −0.066 | −0.084 | 0.015 | 0.692 | |||
84 | 0.672 | 0.097 | 0.802 | −0.105 | −0.135 | 0.020 | 0.820 | |||
91 | 1.4 | 42 | 56 | 0.687 | 0.098 | 0.929 | −0.033 | −0.046 | 0.011 | 0.776 |
70 | 0.662 | 0.096 | 0.892 | −0.058 | −0.080 | 0.013 | 0.842 | |||
84 | 0.628 | 0.090 | 0.825 | −0.092 | −0.128 | 0.017 | 0.918 | |||
91 | 1.5 | 42 | 56 | 0.643 | 0.093 | 0.928 | −0.029 | −0.043 | 0.010 | 0.886 |
70 | 0.621 | 0.091 | 0.903 | −0.052 | −0.077 | 0.011 | 0.928 | |||
84 | 0.590 | 0.085 | 0.838 | −0.083 | −0.123 | 0.014 | 0.967 | |||
91 | 1.6 | 42 | 56 | 0.607 | 0.087 | 0.931 | −0.026 | −0.041 | 0.008 | 0.950 |
70 | 0.585 | 0.085 | 0.901 | −0.047 | −0.075 | 0.009 | 0.965 | |||
84 | 0.557 | 0.080 | 0.846 | −0.075 | −0.119 | 0.012 | 0.985 | |||
91 | 1.7 | 42 | 56 | 0.571 | 0.083 | 0.934 | −0.022 | −0.037 | 0.007 | 0.981 |
70 | 0.551 | 0.081 | 0.907 | −0.042 | −0.070 | 0.008 | 0.990 | |||
84 | 0.526 | 0.076 | 0.857 | −0.067 | −0.113 | 0.010 | 0.996 | |||
91 | 1.8 | 42 | 56 | 0.537 | 0.079 | 0.942 | −0.021 | −0.037 | 0.007 | 0.995 |
70 | 0.519 | 0.077 | 0.910 | −0.039 | −0.069 | 0.007 | 0.996 | |||
84 | 0.496 | 0.073 | 0.858 | −0.062 | −0.111 | 0.009 | 1.000 | |||
91 | 1.9 | 42 | 56 | 0.510 | 0.073 | 0.947 | −0.018 | −0.035 | 0.006 | 0.998 |
70 | 0.494 | 0.072 | 0.920 | −0.034 | −0.065 | 0.006 | 1.000 | |||
84 | 0.472 | 0.069 | 0.875 | −0.056 | −0.106 | 0.008 | 1.000 | |||
91 | 2.0 | 42 | 56 | 0.485 | 0.072 | 0.931 | −0.017 | −0.033 | 0.005 | 0.999 |
70 | 0.470 | 0.070 | 0.910 | −0.032 | −0.065 | 0.006 | 0.999 | |||
84 | 0.450 | 0.067 | 0.875 | −0.052 | −0.104 | 0.007 | 1.000 |