Table 3.

Enablers of malignant aging and neurodegeneration

Intrinsic factors

1. Aging   2. APOE ε4   3. Presenilin mutation   4. AβPP gene mutation   5. Down syndrome

Extrinsic Factors

1. Obesity   2. Diabetes mellitus   3. Insulin Resistance diseases (non-alcoholic fatty liver disease; metabolic syndrome)   4. Cerebrovascular pathologies   5. Infection   6. Head Trauma   7. Severe Inflammatory States   8. General anesthesia   9. Hypoxia   10. Cardiovascular events with hypoperfusion   11. Environmental    a. Air pollution (particulate matter)    b. Herbicides    c. Pesticides   12. Lifestyle    a. Nitrosamine exposures-preserved, processed foods    b. Tobacco    c. Head trauma    d. Heavy alcohol consumption