Figure 2. Overall model performance of APOE-e4 count, polygenic risk score, and Elastic Net SNP models in dementia genetic prediction, UCLA ATLAS sample, stratified by genetic inferred ancestry group.

All models (if not other specified) have regressed out age, sex, and ancestry-specific principal components. Abbreviations: AD, Alzheimer's Disease; AUROC, Area Under the ROC Curve; AUPRC, Area Under the Precision-Recall Curve; EUR, European; PRS, Polygenic Risk Score; SNP, Single-Nucleotide Polymorphism.