Table 1:

Mean standardized PRS₃₁₃ by country in controls in the pooled BCAC dataset, estimated when adjusted for array, 6 PCs country and array, using fitted values adjusted for 6 PCs and array and when using an Empirical Bayes approach adjusted for array.

Country	Number of Controls	Mean PRS3131	Mean PRS adjusted for array and 6 PCs	PRS adjusted for 6 PCs, fitted values2	Empirical Bayes Posterior Mean3
Australia	4049	−0.005	0.01	−0.005	−0.003
Belarus	342	0.07	0.071	0.016	0.064
Belgium	1823	−0.006	−0.007	0.010	−0.002
Canada	2277	0.018	0.019	0.013	0.02
Denmark	5241	−0.013	0.012	−0.031	−0.012
Finland	2083	0.031	0.008	0.010	0.032
France	1372	0.0003	−0.008	0.008	0.004
Germany	8563	0.011	0.004	0.013	0.011
Greece	607	0.232	0.043	0.208	0.199
Ireland	719	−0.118	−0.015	−0.112	−0.092
Israel	724	0.047	0.001	0.062	0.047
Italy	1554	0.115	−0.007	0.131	0.11
Netherlands	4407	0.021	0.043	−0.019	0.022
Norway	217	0.077	0.094	−0.027	0.066
Poland	2554	0.013	0.025	0.010	0.015
Republic of North Macedonia	92	0.25	0.134	0.140	0.129
Russia	120	0.18	0.166	0.044	0.11
Spain	2098	0.057	−0.006	0.057	0.056
Sweden	16680	−0.015	0.005	−0.017	−0.014
UK	16854	−0.01	0.019	−0.023	−0.01
USA	21696	0.029	0.033	0.013	0.029

¹Mean PRS₃₁₃ adjusted for array

²Mean PRS₃₁₃ by country using predicted PRS of each individual; estimated using linear predictor of PRS vs 6 PCs and the command predict () in R.

³Country-specific estimates, means β, using the Empirical Bayes approach, adjusted for array