Table 2:
Mean and SD used to standardize PRS313 of a 50-year-old woman with raw PRS313 equal to 0.341 from Greece and another 50-year-old woman with raw PRS313 equal 0.273 from Ireland, and the risk estimation and categorization when using the CanRisk tool, Greek and Ireland values.
| Samples used for the standardization: | Raw PRS; Mean (SD) | Standardized PRS1 | Percentage based on CanRisk tool | Lifetime risk based on CanRisk tool2 | NICE Risk category |
|---|---|---|---|---|---|
| Individual from Greece with raw PRS313 = 0.341 (falling into the 90–95% percentile category in the full BCAC dataset) | |||||
| CanRisk tool3 | −0.424 (0.611) | 1.253 | 89.5% | 14.1% | Moderate |
| Controls Greece (raw)4 | −0.305 (0.612) | 1.056 | 85.5% | 13.3% | Population |
| Controls Greece adjusted for 6 PCs (raw) | −0.420 (0.696) | 1.094 | 86.3% | 13.5% | Population |
| Controls Greece, using Empirical Bayes method | −0.325 (0.554) | 1.204 | 88.6% | 13.9% | Moderate |
| Individual from Ireland with raw PRS313 = 0.273 (falling into the 85–90% percentile category in the full BCAC dataset) | |||||
| CanRisk tool3 | −0.424 (0.611) | 1.14 | 87.3% | 13.7% | Population |
| Controls Ireland (raw)1 | −0.519 (0.624) | 1.27 | 89.8% | 14.2% | Moderate |
| Controls Ireland adjusted for 6 PCs (raw) | −0.456 (0.74) | 0.985 | 83.8% | 13% | Population |
| Controls Ireland, using EB | −0.503 (0.562) | 1.38 | 91.7% | 14.7% | Moderate |
1
Standardised based on the mean and SD specified in the second column
2
Absolute risk of developing breast cancer by the age of 80
3
When a variant call format (vcf) file is uploaded to the CanRisk tool, a raw PRS313 can be calculated and standardized using the mean (SD) −0.424 (0.611)
4
Adjusted for array type