FIG. 1.

Treatment with ¹⁷⁷Lu-pentixather causes clonogenic cell death in a CXCR4 specific mode and auranofin enhances the toxicity in a SCLC. Panel A: Exponentially growing DMS53, DMS273 and H69AR cells were treated with 30 μM AMD3100 starting 5 min before and during the addition of 10 μCi ¹⁷⁷Lu-pentixather for 3 h followed by assessment of clonogenic survival. N = 2–4 independent experiments; Panel B: Exponentially growing DMS53 and DMS273 were treated with 10 μCi ¹⁷⁷Lu-pentixather and/or 1 μM auranofin for 3 h followed by assessment of clonogenic survival. N = 3 independent experiments. Colony counts were normalized to respective cell lines without treatment. *Significantly different than control, ά significantly different than either drug alone. ND = not determined.