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. Author manuscript; available in PMC: 2025 Jan 1.
Published in final edited form as: Radiat Res. 2024 Jan 1;201(1):35–47. doi: 10.1667/RADE-23-00064.1

FIG. 3.

FIG. 3.

PET/CT imaging using 68Ga-pentixafor demonstrates specific targeting of CXCR4 in lung NECs. The mice showed the expected biodistribution with radiotracer uptake seen in CXCR4-expressing tumors as well as excretion via the kidneys and bladder. Images of mice bearing lung NEC xenografts were taken 2 h after injection with 288 and 307 μCi 68Ga-pentixafor, respectively. Panel A: H727 epithelial lung carcinoid xenograft; Panel B: H720 atypical lung carcinoid xenograft. PET images were set with a scale as 0–1; Panel C: Bio-distribution of 68Ga-pentixafor was measured ~1 h 45 min after injection.