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. Author manuscript; available in PMC: 2024 Feb 26.
Published in final edited form as: Nat Struct Mol Biol. 2023 Mar 27;30(6):735–739. doi: 10.1038/s41594-023-00951-7

Extended Data Fig. 3 |. CaV1.2(ΔC)/CaVβ3/CaVα2δ-1:GBP Cryo-EM maps.

Extended Data Fig. 3 |

a, CaV1.2(ΔC)/CaVβ3/CaVα2δ-1 side view (left) and extracellular (right) view. Subunits are colored: CaV1.2 (slate) and CaVβ3 (violet). CaVα2δ domains are colored as: dCache1 (aquamarine), dCache2 (orange), VWA:MIDAS (green), and CaVδ (yellow). Grey bars denote the membrane. b-e, CaVα2δ-1 subdomain representative maps for b, VWA:MIDAS domain, c, dCache1, d, dCache2:CaVδ. Part of CaVδ completes the second β-barrel subdomain of dCache2, e, CaVδ. f, GBP-binding site. Maps are rendered at 9–10σ. Domain colors are as in a.