Fig 2. Genes and pathways affected by endometrial cancer mutations.

A. Highly mutated genes detected in endometrial cancer patients. Shown are only those genes that are mutated in at least 100 patients out of 3213 (66 genes). For each of the 66 genes, we computed their occurrence in endometrial cancers compared with occurrence in all other cancers (expressed as percent). Red stars represent those genes with highest frequency of driver mutations. Complete data in S2 and S4 Tables. B. Biological processes affected by most frequent mutations in endometrial cancers. Only those processes with a string score above 0.1 are shown. C. Percent driver and passenger mutations for genes in A as determined by the CHASM algorithm.