Table 1. Top 10 stabilizing or destabilizing mutations predicted to affect protein stability via CUPSAT organized by gene.
| Gene/Protein | Mutation | Predicted ΔΔG (kcal/mol) | Predicted Effect |
|---|---|---|---|
| FGFR2 | S252W | -12.66 | Destabilizing |
| PTEN | C136R | -3.93 | Destabilizing |
| PIK3CA | Y1021H | -1.66 | Destabilizing |
| CTNNB1 | D32N | 4.38 | Stabilizing |
| CTNNB1 | D32H | -4.68 | Destabilizing |
| CTNNB1 | D32Y | -2.69 | Destabilizing |
| CTNNB1 | G34V | 1.4 | Stabilizing |
| CTNNB1 | G34E | -8.24 | Destabilizing |
| TP53 | R248G | 1.71 | Stabilizing |
| TP53 | R248Q | 2.3 | Stabilizing |
| TP53 | R248W | 4.65 | Stabilizing |
| TP53 | R273L | 5.41 | Stabilizing |
| TP53 | R273C | 17.86 | Stabilizing |
| TP53 | R273H | 3.2 | Stabilizing |