Table 2. Mutations identified to significantly affect protein structure.
| Protein | Mutation | Observed Electrostatic Change | Reduces Polar Interactions? | Predicted ΔΔG (kcal/mol) |
|---|---|---|---|---|
| FGFR2 | S252W | Neutral to Neutral | No | -12.66 |
| PTEN | R130P | Basic to Less Basic | Yes | -0.46 |
| PIK3CA | E545A | Acidic to Neutral | Yes | -0.49 |
| PIK3CA | E545G | Acidic to Neutral | Yes | -0.69 |
| CTNNB1 | D32H | Acidic to Neutral | No | -4.68 |
| CTNNB1 | G34E | Neutral to Acidic | No | -8.24 |
| TP53 | R273H | Basic to Neutral | Yes | 3.2 |
| TP53 | R273C | Basic to Neutral | Yes | 17.86 |
| TP53 | R273L | Basic to Less Basic | Yes | 5.41 |