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. 2024 Feb 26;19(2):e0297080. doi: 10.1371/journal.pone.0297080

Fig 2. Cell proliferation is stimulated by 17b-estradiol and an ERa agonist which is negated by tamoxifen: Incorporation of BrdU by breast cancer cells MCF7, T47D and BT483 as a percentage of the vehicle control (+/- SEM of 3 separate assays with 8 experimental replicates).

Fig 2

CON = vehicle control (0.1% DMSO); E2 = 17b-estradiol (10nM); TAM = tamoxifen (2μM); PPT (100nM), ERB = ERB-041 (100nM) Cells were incubated for 48 hours. ANOVA (Dunnett’s multiple comparison) statistical significance is displayed on the graph above the bars (* denotes significance vs CON. # denotes significance vs E2.). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001, ns non-significant.