TABLE 2.

Top 10 Associations between AD loci and memory performance and memory decline GWAS.

							Non‐Hispanic white (NHW)				Non‐Hispanic black (NHB)
Variant	Gene a	Chr	BP b	RA	OA	Cross Ancestry p‐value	EAF c	β (βSE)	p‐value	N	EAFc	β (βSE)	p‐value	N
Memory performance
rs429358	APOE	19	44908684	C	T	2.03 ×€€10−33	0.16	−1.34 ×€€10−1 (1.13 ×€€10−2)	3.32 ×€€10−32	7046	0.204	−8.20 ×€€10−2 (2.83 ×€€10−2)	3.74 ×€€10−3	625
rs6733839	BIN1	2	127135234	T	C	3.96 ×€€10−7	0.402	−2.97 ×€€10−2 (6.49 ×€€10−3)	4.70 ×€€10−6	24209	0.405	−3.61 ×€€10−2 (1.63 ×€€10−2)	2.69 ×€€10−2	3367
rs4844610	CR1	1	207629207	A	C	8.43 ×€€10−6	0.193	−3.38 ×€€10−2 (8.11 ×€€10−3)	3.04 ×€€10−5	24214	0.039	−1.25 ×€€10−1 (5.52 ×€€10−2)	2.40 ×€€10−2	2844
rs7920721	ECHDC3	10	11678309	G	A	1.32 ×€€10−5	0.389	−2.99 ×€€10−2 (6.51 ×€€10−3)	4.55 ×€€10−6	24215	0.16	1.43 ×€€10−2 (2.84 ×€€10−2)	6.14 ×€€10−1	2844
rs6931277	HLA‐DRB1	6	32615580	T	A	1.81 ×€€10−4	0.166	3.02 ×€€10−2 (8.57 ×€€10−3)	4.32 ×€€10−4	24216	0.097	3.43 ×€€10−2 (2.66 ×€€10−2)	1.98 ×€€10−1	3367
rs9473117	CD2AP	6	47463548	C	A	6.28 ×€€10−4	0.28	−2.01 ×€€10−2 (7.03 ×€€10−3)	4.20 ×€€10−3	24216	0.214	−4.14 ×€€10−2 (1.94 ×€€10−2)	3.26 ×€€10−2	3367
rs2632516	MIR142/TSPOAP1‐AS1	17	58331728	G	C	2.03 ×€€10−3	0.443	1.60 ×€€10−2 (6.31 ×€€10−3)	1.10 ×€€10−2	24216	0.402	−4.71 ×€€10−2 (2.08 ×€€10−2)	2.39 ×€€10−2	2844
rs3848143	SNX1	15	64131307	G	A	3.82 ×€€10−3	0.222	−2.33 ×€€10−2 (7.66 ×€€10−3)	2.36 ×€€10−3	24214	0.389	−2.22 ×€€10−3 (2.10 ×€€10−2)	9.15 ×€€10−1	2844
rs113260531	SCIMP	17	5235685	A	G	3.86 ×€€10−3	0.124	−2.67 ×€€10−2 (9.62 ×€€10−3)	5.45 ×€€10−3	24216	0.206	−1.74 ×€€10−2 (1.92 ×€€10−2)	3.66 ×€€10−1	3367
rs11218343	SORL1	11	121564878	C	T	6.20 ×€€10−3	0.038	4.14 ×€€10−2 (1.65 ×€€10−2)	1.20 ×€€10−2	24185	0.084	3.22 ×€€10−2 (2.87 ×€€10−2)	2.62 ×€€10−1	3365
Memory decline
rs429358	APOE	19	44908684	C	T	3.20 ×€€10−59	0.159	−1.98 ×€€10−2 (1.23 ×€€10−3)	3.87 ×€€10−58	6425	0.204	−1.15 ×€€10−2 (3.67 ×€€10−3)	1.78 ×€€10−3	588
rs6733839	BIN1	2	127135234	T	C	2.21 ×€€10−11	0.401	−4.52 ×€€10−3 (7.49 ×€€10−4)	1.66 ×€€10−9	19700	0.405	−6.21 ×€€10−3 (2.06 ×€€10−3)	2.61 ×€€10−3	2617
rs4844610	CR1	1	207629207	A	C	7.14 ×€€10−8	0.192	−4.77 ×€€10−3 (9.36 ×€€10−4)	3.65 ×€€10−7	19705	0.039	−1.65 ×€€10−2 (6.60 ×€€10−3)	1.24 ×€€10−2	2122
rs9473117	CD2AP	6	47463548	C	A	1.03 ×€€10−6	0.28	−3.62 ×€€10−3 (8.13 ×€€10−4)	8.66 ×€€10−6	19707	0.214	−5.23 ×€€10−3 (2.47 ×€€10−3)	3.41 ×€€10−2	2617
rs7920721	ECHDC3	10	11678309	G	A	1.51 ×€€10−5	0.389	−3.40 ×€€10−3 (7.49 ×€€10−4)	5.83 ×€€10−6	19706	0.16	1.63 ×€€10−3 (3.45 ×€€10−3)	6.37 ×€€10−1	2122
rs113260531	SCIMP	17	5235685	A	G	1.24 ×€€10−4	0.124	−4.19 ×€€10−3 (1.11 ×€€10−3)	1.52 ×€€10−4	19707	0.207	−2.28 ×€€10−3 (2.42 ×€€10−3)	3.45 ×€€10−1	2617
rs73223431	PTK2B	8	27362470	T	C	6.04 ×€€10−4	0.361	−2.32 ×€€10−3 (7.61 ×€€10−4)	2.23 ×€€10−3	19707	0.259	−3.96 ×€€10−3 (2.30 ×€€10−3)	8.50 ×€€10−2	2617
rs112403360	ANKH	5	14724304	A	T	8.56 ×€€10−4	0.075	−4.28 ×€€10−3 (1.36 ×€€10−3)	1.66 ×€€10−3	19707	0.096	−3.83 ×€€10−3 (3.45 ×€€10−3)	2.67 ×€€10−1	2617
rs11218343	SORL1	11	121564878	C	T	1.14 ×€€10−3	0.038	6.23 ×€€10−3 (1.88 ×€€10−3)	9.31 ×€€10−4	19683	0.084	2.48 ×€€10−3 (3.65 ×€€10−3)	4.96 ×€€10−1	2616
rs62374257	COX7C	5	86927378	C	T	1.24 ×€€10−3	0.231	−3.05 ×€€10−3 (8.62 ×€€10−4)	4.21 ×€€10−4	19707	0.046	1.11 ×€€10−2 (5.95 ×€€10−3)	6.13 ×€€10−2	2122

Note: Boldface indicates p < 0.05.

Abbreviations: AD, Alzheimer's disease; BP, base pair; Chr, chromosome; EAF, effect allele frequency; GWAS, genome‐wide associations studies; OA, other allele; RA, reference allele.

^aGene previously reported in prior AD GWAS.

^b GRCh38 assembly.

^cFrequency across all cohorts included in analysis.