. 2024 Jan 22;11(3):nwae029. doi: 10.1093/nsr/nwae029

Table 1.

Kinetic parameters for (−)-morphine and (+)-morphine interacting with MOR.

		Binding time t_in (ns)	Residence time t_out	Association rate constant k_on [1/(ns mM)]
D^2.50Charged_D^3.32Charged_MOR
	(−)-morphine	99.07 ± 5.37	0.30 ± 0.02 s	0.01434 ± 0.00067
	(+)-morphine	63.79 ± 2.12	37.36 ± 4.16 μs	0.02227 ± 0.00109
D^2.50Charged_D^3.32Neutral_MOR
	(−)-morphine	336.32 ± 16.26	4.36 ± 0.61 μs	0.00422 ± 0.00022
	(+)-morphine	326.46 ± 46.44	49.87 ± 11.87 μs	0.00435 ± 0.00030
D^2.50Neutral_D^3.32Charged_MOR
	(−)-morphine	523.36 ± 38.43	1.90 ± 0.22 μs	0.00271 ± 0.00013
	(+)-morphine	46.82 ± 1.21	4.57 ± 0.65 ms	0.03035 ± 0.00076
D^2.50Neutral_D^3.32Neutral_MOR
	(−)-morphine	1153.46 ± 68.69	52.72 ± 3.42 μs	0.001231 ± 0.00010
	(+)-morphine	198.76 ± 13.02	59.40 ± 6.05 μs	0.00715 ± 0.00058