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. Author manuscript; available in PMC: 2024 Feb 26.
Published in final edited form as: Cell. 2022 Jan 6;185(1):77–94. doi: 10.1016/j.cell.2021.10.029

Figure 4: Axon degeneration and immune response to injury.

Figure 4:

(A) Degenerative mechanisms following injury: An intact axon before injury; an injured axon undergoing Wallerian degeneration distal to the lesion site (asterisk). Dotted regions of the intact and injured axons are shown magnified below: retraction bulb (arrow) sealing the axolemma at the proximal end of an injured axon and microglia (pink) clearing axonal debris.

(B) Injury in the PNS: Schwann cells in the PNS myelinate regenerating axons (top); macrophages phagocytose axonal debris (bottom, pink).