Table 3.
Comparison of mPFS between primary tumor site and baseline CEA levels
| Parameter | N | mPFS | 95% CI | p value |
|---|---|---|---|---|
| Gender | 0.839 | |||
| Male | 24 | 7.8 | 7.1–8.5 | |
| Female | 15 | 6.9 | 4.4–9.4 | |
| Age, years | 0.201 | |||
| ≥60 | 18 | 8.0 | 7.5–8.6 | |
| <60 | 21 | 6.9 | 5.3–8.5 | |
| Mean age, years | 57.95±9.81 | |||
| Disease location | 0.047 | |||
| Colon | 20 | 8.0 | 4.8–11.2 | |
| Rectum | 19 | 6.6 | 5.6–7.7 | |
| PS score | 0.244 | |||
| 0 | 9 | 10.2 | 6.8–13.6 | |
| 1 | 30 | 7.3 | 6.4–8.2 | |
| Whether the primary tumor was resected | 0.915 | |||
| Yes | 28 | 7.3 | 6.2–8.4 | |
| No | 11 | 7.8 | 6.6–9.0 | |
| Metastasis time | 0.360 | |||
| Synchronous | 23 | 7.8 | 7.4–8.2 | |
| Asynchronous | 16 | 7.3 | 6.8–7.8 | |
| Degree of differentiation | 0.728 | |||
| Low | 10 | 8.1 | 5.6–10.6 | |
| Medium | 29 | 7.7 | 7.2–8.2 | |
| Maintenance baseline CEA | 0.012 | |||
| ≤5 | 17 | 9.5 | 6.7–12.3 | |
| >5 | 22 | 6.2 | 4.4–8.0 | |
| MSI status | 0.807 | |||
| MSI-H | 2 | 5.9 | – | |
| MSS/MSI-L | 29 | 7.8 | 7.2–8.5 | |
| Not tested | 8 | 7.4 | 7.1–7.7 | |
| Number of metastatic sites | 0.319 | |||
| 1 site | 16 | 8.1 | 6.4–9.8 | |
| 2 or more | 23 | 7.7 | 7.2–8.2 | |
| Number of induction treatment cycles | 0.836 | |||
| 6–8 | 8 | 7.8 | 3.9–11.7 | |
| 9–12 | 31 | 7.4 | 6.4–8.4 | |
| Best response to induction therapy | 0.713 | |||
| CR | 2 | 5.1 | – | |
| PR | 17 | 7.4 | 4.9–9.9 | |
| SD | 20 | 7.8 | 7.1–8.5 |
CR, complete response; PR, partial response; SD, stable disease.