Table 1.
Odds Ratio and Diagnostic Performance of the “Thickened Structure” and “Methylated Contrast Phenotype” for pMGMT Methylation Status in GBM. † Indicates p < 0.05.
| Positive number | p Value | pMGMT-Met GBM prediction | pMGMT-Unmet GBM prediction | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | Sensitivity | Specificity | Odds ratio | 95% CI | Sensitivity | Specificity | ||||
| KANSAI cohort (exploratory) Total 193 subjects |
Thick. Struc. (+) | 98 | 0.67 | 1.16 | 0.65–1.99 | 52.0% | 51.0% | 0.87 | 0.50–1.55 | 49.0% | 47.4% |
| Methyl. CP (+) | 94 | 0.01† | 2.27 | 1.23–4.05 | 60.6% | 61.5% | 0.44 | 0.25–0.80 | 38.5% | 41.2% | |
| Thick. Struc.(+)/ Methyl. CP (+) | 56 | 0.01† | 2.45 | 1.33–4.75 | 66.1% | 80.2% | 0.40 | 0.21–0.75 | 19.8% | 61.9% | |
| Thick. Struc.(+)/ Methyl. CP (-) | 42 | 0.01† | 0.41 | 0.19–0.82 | 33.3% | 70.8% | 2.44 | 1.21–5.15 | 29.2% | 85.6% | |
| Thick. Struc.(-)/ Methyl. CP (+) | 38 | 0.86 | 1.13 | 0.54–2.21 | 52.6% | 81.3% | 0.89 | 0.45–1.85 | 18.8% | 79.4% | |
| Thick. Struc.(-)/ Methyl. CP (-) | 57 | 0.43 | 0.77 | 0.42–1.40 | 45.6% | 67.7% | 1.30 | 0.72–2.41 | 32.3% | 73.2% | |
| TCIA/ TCGA cohort (validation) Total 93 subjects |
Thick. Struc. (+) | 35 | 0.67 | 0.77 | 0.33–1.76 | 34.7% | 59.1% | 1.30 | 0.57–3.03 | 40.9% | 65.3% |
| Methyl. CP (+) | 56 | 0.01† | 3.32 | 1.43–7.63 | 73.5% | 54.6% | 0.30 | 0.13–0.70 | 45.5% | 26.5% | |
| Thick. Struc.(+)/ Methyl. CP (+) | 22 | 0.14 | 2.33 | 0.87 – 5.93 | 30.6% | 84.1% | 0.43 | 0.17–1.15 | 15.9% | 69.4% | |
| Thick. Struc.(+)/ Methyl. CP (-) | 13 | 0.01† | 0.13 | 0.03–0.61 | 4.1% | 75.0% | 7.83 | 1.63–36.56 | 25.0% | 95.9% | |
| Thick. Struc.(-)/ Methyl. CP (+) | 34 | 0.20 | 1.79 | 0.77–4.00 | 42.9% | 70.5% | 0.56 | 0.25–1.30 | 29.6% | 57.1% | |
| Thick. Struc.(-)/ Methyl. CP (-) | 24 | 0.48 | 0.69 | 0.27–1.71 | 22.5% | 70.5% | 1.45 | 0.58–3.77 | 29.6% | 77.6% | |