Table 1.
Demographic and phenotypic features of children and adolescents with ulcerative colitis [UC] or IBD-unclassified [IBD-U] at time of diagnosis.
| Acute severe colitis n = 105 |
Mild to moderate colitis n = 273 |
p-value | |
|---|---|---|---|
| UC: IBD-U | 96 [91%] 9 [9%] | 241 [88%] 32 [12%] | 0.65 |
| Male n [%] | 44 [42%] | 143 [52%] | 0.07 |
| Age at diagnosis | 14 [11.2-15.7]* | 13 [9.7-15.3] | 0.05 |
| Duration of symptoms [weeks] | 8 [4-19] | 14 [6.5-29] | <0.001 |
| Family history [1st-degree relative] | 17 [16%] | 46 [17%] | 0.80 |
| Ethnicity | |||
| Caucasian | 65 [65%] | 150 [58%] | 0.009 |
| South Asian | 14 [14%] | 42 [16%] | |
| African/Caribbean | - | 15 [6%] | |
| Other | 10 [10%] | 12 [4%] | |
| Mixed | 11 [11%] | 42 [16%] | |
| Disease extent | |||
| E1 | - | 25 [9%] | <0.001 |
| E2 | - | 21 [8%] | |
| E3 | 14 [13%] | 34 [13%] | |
| E4 | 91 [87%] | 187 [70%] | |
| Clinical disease activity at presentation | |||
| PUCAI | 75 [70-80] | 45 [30-55] | <0.001 |
| Mayo endoscopic score | |||
| Mayo 1 | - | 90 [33%] | <0.001 |
| Mayo 2 | 40 [38%] | 137 [51%] | |
| Mayo 3 | 65 [62%] | 44 [16%] | |
| Laboratory parameters at presentation | |||
| Albumin g/L | 31 [25-35] | 40 [35-43] | <0.001 |
| Hb g/L | 104 [86-121] | 115 [99-127] | <0.001 |
| CRP mg/L | 14 [5-36] | 5 [1-9.9] | <0.001 |
| ESR mm/h | 29 [18-50] | 22 [12-38] | 0.002 |
| Platelets [109/L] | 416 [334-528] | 376 [304-469] | 0.008 |
| Anthropometric measurements at presentation | |||
| Height z-score | 0.28 ± 1.16 | 0.19 ± 1.09 | 0.51 |
| Weight z-score | -0.14 ± 1.13 | -0.02 ± 1.28 | 0.41 |
| BMI z-score | -0.41 ± 1.27 | -0.26 ± 1.46 | 0.34 |
Values are presented as n [%], mean ± standard deviation, or median [interquartile range], as appropriate
PUCAI: Pediatric Ulcerative Colitis Activity Index; PGA: Physician’s Global Assessment; ESR: erythrocyte sedimentation rate; CRP: C reactive protein; Hb: haemoglobin.
*Seven children with ASUC were diagnosed prior to age 6 years [age range: 2.75-5.58 years].