Table 2.
Demographic and phenotypic features of children and adolescents newly diagnosed with ASUC, stratified by steroid refractory sand steroid responsive.
| Steroid refractory n = 54 |
Steroid responsive n = 51 | p-value | |
|---|---|---|---|
| Male n [%] | 28 [52%] | 16 [31%] | 0.03 |
| Age at diagnosis | 14.4 [12.4-16] | 13.0 [9.6-15.3] | 0.04 |
| Duration of symptoms [weeks] | 9 [4-21] | 8 [4-20] | 0.44 |
| Family history [1st-degree relative] | 9 [17%] | 8 [16%] | 0.89 |
| Ethnicity** | |||
| Caucasian | 36 [67%] | 29 [63%] | 0.98 |
| South Asian | 7 [13%] | 7 [15%] | |
| Other | 5 [9%] | 5 [11%] | |
| Mixed | 6 [11%] | 5 [11%] | |
| Disease extent | |||
| E3 | 7 [13%] | 7 [14%] | 0.91 |
| E4 | 47 [87%] | 44 [86%] | |
| Clinical disease activity at presentation | |||
| PUCAI | 80 [75-85] | 75 [70-80] | 0.02 |
| Endoscopic Mayo score | |||
| Mayo 2 | 19 [35%] | 21 [41%] | 0.53 |
| Mayo 3 | 35 [65%] | 30 [59%] | |
| PGA score | |||
| Moderate | 4 [7%] | 5 [10%] | 0.66 |
| Severe | 50 [93%] | 46 [90%] | |
| Laboratory parameters at presentation | |||
| Albumin g/L | 28 [24.2-33] | 33 [29-38] | <0.001 |
| Hb g/L | 108 [84-120] | 102 [91-121] | 0.90 |
| CRP mg/L | 16.7 [6.1-37.0] | 10.2 [3.2-36.5] | 0.24 |
| ESR mm/h | 30 [18.8-40.3] | 28 [17.5-54] | 0.98 |
| Platelets [109/L] | 436 [340-530] | 384 [323-527] | 0.53 |
| Anthropometric measurements at presentation | |||
| Height z-score | 0.10 ± 1.11 | 0.46 ± 1.20 | 0.12 |
| Weight z-score | -0.38 ± 1.17 | 0.13 ± 1.03 | 0.02 |
| BMI z-score | -0.59 ± 1.28 | -0.24 ± 1.24 | 0.17 |
ASUC, acute, severe ulcerative colitis; PUCAI: Pediatric Ulcerative Colitis Activity Index; PGA: Physician’s Global Assessment; ESR: erythrocyte sedimentation rate; CRP: C reactive protein; Hb: haemoglobin.
*p-value <0.05, for binary/ordinal variable chi square test and for continuous variables Mann-Whitney test.