FIGURE 4.

Peripheral TRPV1 and TRPV2 Nociception Channels Have Limited Translational Applicability to Humans. Relative expression of trpv1 and trpv2 was determined using qPCR from the colon, heart, kidney, liver, MLN, spleen, and visceral fat from mice, rats and NHP. (a) Trpv1 was detected partially in the colon (3/5 mice), kidney (2/5 mice), and the visceral fat (3/5 mice), having significantly different expression levels among the visceral fat and the expression levels in the heart and liver. (b) Trpv1 was detected in the colon, heart (5/6 rats), kidney, liver, MLN (5/6 rats), and spleen (5/6 rats). Significant differences were found between the kidney and the other organs, except for the colon which showed comparable expression levels. (c) Trpv1 was detected in the kidney (1/4 rhesus) and the spleen (2/4 rhesus). (d) Trpv2 mRNA was detected in the heart, kidney (4/5 mice), liver (1/6 mice), spleen, and visceral fat, having higher significant levels in the last two. (e) Trpv2 was detected in the colon (1/6 rats), heart (4/6 rats), kidney (4/5 rats), MLN, and spleen. Trpv2 was similar between immune organs, and they are both significantly different when compared with the metabolic organs. (f) Trpv2 showed broader detection, being detected in the liver (2/4 rhesus), MLN, spleen, and visceral fat. Data are graphed as the mean ± SD.