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. 2024 Jan 26;6(2):226–237. doi: 10.1038/s42255-023-00970-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Quantile-quantile plot showing the distribution of the observed P values from the gene-level rare coding variant association test against the expected distribution under the null hypothesis. The grey zone indicates the 95% confidence interval. GC, genomic inflation factor.