Table 2.
Initial TKI-induced ILD and TKI re-administration-induced ILD
| Characteristic | Initial TKI-induced ILD (n = 58) | TKI re-administration-induced ILD (n = 13) |
|---|---|---|
| Incidence | NA | 13/58 (22.4%) |
| Onset, days from TKI, median | 61 (4–537) | 66 (3–446) |
| CTCAE Grade, 1/2/3/4 | 26/20/11/1 | 3/6/4/0 |
| Radiological pattern of TKI-induced ILD | ||
| DAD | 4 | 0 |
| Non-DAD | 53 | 13 |
| HP/OP/AEP/NSIP/unclassifiable | 11/23/8/4/7 | 3/5/1/2/2 |
| Undetermined | 1 | 0 |
| Treatment with corticosteroid, yes (with pulse therapy)/no | 30 (8)/28 | 9 (4)/4 |
AEP acute eosinophilic pneumonia, DAD diffuse alveolar damage, HP hypersensitivity pneumonia, ILD interstitial lung disease, NA not assessed, NSIP non-specific interstitial pneumonia, OP organizing pneumonia, TKI tyrosine kinase inhibitor