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. 2024 Feb 4;27(2):324–342. doi: 10.1007/s10120-023-01461-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Schematic (A) of the in vivo treatment experimental plan. Serum TLR6 and IL-8 expression (B, C) and gastric mucosa TLR6 and IL-8 IHC staining (D, E) of the H. pylori-negative Mongolian gerbils or in the H. pylori-infected gerbils after 24 h, 48 h and 72 h intraperitoneal administration of Pam2CSK4 or DMSO. pJNK expression (F) in the gastric mucosa of H. pylori-negative Mongolian gerbils or in the H. pylori-infected gerbils after 72 h intraperitoneal administration of Pam2CSK4 or DMSO. The Immunofluorescence staining of CD11b⁺/Ly6G⁺ cells (G), monocyte/macrophage (I), the number of CD11b⁺/Ly6G⁺ cells (H) and the number of monocyte/macrophage (J) in gastric mucosa of H. pylori-negative gerbils, H. pylori-positive gerbils treated with DMSO or Pam2CSK4. The level of H. pylori 23srRNA (K) in gastric mucosa of H. pylori-positive Mongolian gerbils treated with DMSO or Pam2CSK4. IHC staining of TLR6 expression (L) in the gastric mucosa of patients. × 100. The average optical density (AOD) of TLR6 expression (M) in patients’ gastric mucosa. All experiment were performed in triplicate and all data represents means ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05

Fig. 6 — Schematic (A) of the in vivo treatment experimental plan. Serum TLR6 and IL-8 expression (B, C) and gastric mucosa TLR6 and IL-8 IHC staining (D, E) of the H. pylori-negative Mongolian gerbils or in the H. pylori-infected gerbils after 24 h, 48 h and 72 h intraperitoneal administration of Pam2CSK4 or DMSO. pJNK expression (F) in the gastric mucosa of H. pylori-negative Mongolian gerbils or in the H. pylori-infected gerbils after 72 h intraperitoneal administration of Pam2CSK4 or DMSO. The Immunofluorescence staining of CD11b⁺/Ly6G⁺ cells (G), monocyte/macrophage (I), the number of CD11b⁺/Ly6G⁺ cells (H) and the number of monocyte/macrophage (J) in gastric mucosa of H. pylori-negative gerbils, H. pylori-positive gerbils treated with DMSO or Pam2CSK4. The level of H. pylori 23srRNA (K) in gastric mucosa of H. pylori-positive Mongolian gerbils treated with DMSO or Pam2CSK4. IHC staining of TLR6 expression (L) in the gastric mucosa of patients. × 100. The average optical density (AOD) of TLR6 expression (M) in patients’ gastric mucosa. All experiment were performed in triplicate and all data represents means ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05