Table 4.
Univariate and multivariate logistic regression analysis for risk factors of HBV reactivation.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| OR(95%CI) | P value | OR(95%CI) | P value | |
| Age (≥50 years) | 0.419 (0.146-1.199) | 0.105 | ||
| Sex(male) | 0.663 (0.083-5.314) | 0.699 | ||
| History of alcoholism (yes) | 0.839 (0.26-2.713) | 0.77 | ||
| Antiviral prophylaxis (yes) | 0.187 (0.064-0.547) | 0.002 | 0.193 (0.064-0.58) | 0.003 |
| HBsAg (+) | 0.835 (0.177-3.932) | 0.82 | ||
| HBeAg (+) | 0.527 (0.115-2.411) | 0.409 | ||
| HBV DNA (>2000 IU/ml) | 0 | 0.996 | ||
| Child Pugh score (B) | 1.197 (0.254-5.636) | 0.82 | ||
| Tumor diameter (≥10cm) | 5.312 (1.176-24.005) | 0.03 | 5.132 (1.114-23.634) | 0.036 |
| Tumor number (multiple) | 0.904 (0.244-3.345) | 0.88 | ||
| PVTT (≥2) | 2.801 (0.357-21.984) | 0.327 | ||
| Extra−hepatic metastasis (yes) | 0.987 (0.329-2.963) | 0.981 | ||
| AFP (≥400ng/ml) | 3.026 (0.835-10.96) | 0.092 | 2.379 (0.594-9.531) | 0.221 |
| ALT (≥50IU/L) | 0.665 (0.222-1.987) | 0.465 | ||
| Albumin (≥35 g/L) | 0.573 (0.152-2.163) | 0.411 | ||
| TBil (≥17.1μmol/L) | 0.475 (0.166-1.357) | 0.475 | ||
| WBC (≥11*109/L) | 1.663 (0.442-6.264) | 0.452 | ||
| Cycles of HAIC (≥4) | 2.963 (0.818-10.734) | 0.098 | 2.074 (0.523-8.217) | 0.299 |
HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; DNA, deoxyribonucleic acid; PVTT, portal vein tumor thrombosis; AFP alpha−fetoprotein, ALT, alanine aminotransferase; TBil, total bilirubin; WBC, white blood cell; HAIC hepatic arterial infusion chemo−therapy.