Table 7.

Relationship between the density of CD68⁺ macrophage in tubulointerstitium and response to treatment under different stratification.

Subgroupstratification		Cases	HR (95%CI)	P-value	P for interaction
Gender	male	66	0.998 (0.996, 1.000)	0.0194	0.7779
	female	364	0.997 (0.996, 0.998)	<0.0001
Age	≤38	334	0.998 (0.997, 0.999)	<0.0001	0.0234
	>38	96	0.994 (0.991, 0.997)	0.0004
SLEDAI	≤12	317	0.997 (0.996, 0.998)	<0.0001	0.8869
	>12	113	0.997 (0.995, 0.999)	0.0058
SCr	≤1.2	312	0.999 (0.997, 1.000)	0.0470	0.4323
	>1.2	118	0.998 (0.996, 0.999)	0.0021
UA	≤380	192	0.998 (0.996, 1.000)	0.0117	0.7326
	>380	238	0.997 (0.996, 0.999)	<0.0001
eGFR	>60	118	0.997 (0.996, 0.999)	0.0005	0.1434
	≤60	312	0.999 (0.997, 1.000)	0.0831
UPRO	≤2.5	184	0.997 (0.996, 0.999)	0.0004	0.8852
	>2.5	246	0.997 (0.996, 0.998)	<0.0001
A-dsDNA	negative	185	0.997 (0.996, 0.999)	0.0001	0.8366
	positive	245	0.997 (0.996, 0.999)	<0.0001
C3	≤0.46	254	0.997 (0.996, 0.998)	<0.0001	0.9764
	>0.46	176	0.997 (0.996, 0.999)	0.0001
C4	≤0.09	248	0.998 (0.996, 0.999)	0.0002	0.7275
	>0.09	182	0.997 (0.996, 0.999)	<0.0001
CD4	≤260	173	0.998 (0.996, 0.999)	0.0001	0.5375
	>260	257	0.997 (0.996, 0.998)	<0.0001
PLN	NO	54	0.996 (0.993, 1.000)	0.0232	0.5639
	YES	376	0.997 (0.996, 0.998)	<0.0001
AIs	≤3	66	0.997 (0.994, 1.000)	0.0311	0.8287
	>3	364	0.997 (0.996, 0.998)	<0.0001
CIs	≤3	361	0.998 (0.997, 0.999)	<0.0001	0.4082
	>3	69	0.997 (0.995, 0.999)	0.0079

SLEDAI, Systemic Lupus Erythematous Disease Activity; SCr, serum creatinine; UA, blood uric acid; eGFR, estimated glomerular filtration rate; UPRO, urinary protein quantitation; C3, complement 3; C4, complement 4; CD4, CD4+ cell count; LP, Lupus podocytopathy; AIs, activity index score; CIs, activity index score.