Table 2.
Input configurations that cover eight different biological scenarios of the type 1 IFN pathway with or without infection and in the presence or absence of drugs.
| Input configurations | C1 | C2 | C3 | C4 | C5 | C6 | C7 | C8 |
|---|---|---|---|---|---|---|---|---|
| Viral components | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
| Immune response | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| IFN secretion | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
| Azithromycin | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| GRL0617 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| MNS | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| Projection of the stable states to the four outputs | C1 | C2 | C3 | C4 | C5 | C6 | C7 | C8 |
| ISG_expression_antiviral_response_phenotype | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| Viral_replication_phenotype | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
| Proinflammatory_cytokine_expression_Inflammation | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 |
| type_I_IFN_response_phenotype | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |