Table 2.
Biodistribution at 1 h and 3 h Post-injection in Tumor-Bearing Micea
| [211At]At-NpGT | [125I]I-NpGT | [18F]F-NpGT | [125I]I-IMT | |||||
|---|---|---|---|---|---|---|---|---|
| Time after Injection | 1 h | 3 h | 1 h | 3 h | 1 h | 3 h | 1 h | 3 h |
| Blood | 1.39 ± 0.33 c | 0.49 ± 0.09 | 1.86 ± 0.09 | 0.54 ± 0.27 | 1.91 ± 0.35 | 0.37 ± 0.10 | 1.22 ± 0.24f,g | 0.22 ± 004e,f |
| Liver | 8.09 ± 1.34 | 2.25 ± 0.55 | 8.09 ± 1.22 | 2.94 ± 1.63 | 7.28 ± 1.30 | 1.40 ± 0.53 | 0.80 ± 0.20f,g | 0.14 ± 0.04e,f |
| Spleen | 2.22 ± 0.58 | 0.94 ± 0.17b | 2.30 ± 0.58 | 0.56 ± 0.24 | 2.36 ± 0.68 | 0.63 ± 0.20 | 1.01 ± 0.22f,e,g | 0.16 ± 0.05e,f,g |
| Kidney | 32.8 ± 5.23c | 14.8 ± 3.41c | 25.0 ± 4.25d | 10.4 ± 4.42d | 13.5 ± 3.58 | 4.06 ± 1.53 | 19.6 ± 3.37 | 2.34 ± 0.31e,f |
| Pancreas | 16.6 ± 1.03b | 3.33 ± 1.17 | 30.1 ± 3.05 | 7.36 ± 4.07 | 20.3 ± 4.20 | 8.54 ± 2.55 | 11.9 ± 4.48 f | 0.56 ± 0.21f,g |
| Heart | 1.09 ± 0.20 | 0.74 ± 0.73 | 1.36 ± 0.20 | 0.43 ± 0.18 | 1.16 ± 0.30 | 0.56 ± 0.11 | 1.12 ± 0.29 | 0.11 ± 0.03 |
| Lung | 2.46 ± 0.41c | 1.59 ± 1.10 | 2.14 ± 0.37d | 0.58 ± 0.22 | 1.89 ± 0.35 | 0.65 ± 0.17 | 1.00 ± 0.39 e, f | 0.17 ± 0.03e |
| Muscle | 0.95 ± 0.53 | 0.42 ± 0.07 | 0.96 ± 0.14 | 0.59 ± 0.27 | 0.48 ± 0.08 | 0.62 ± 0.48 | 1.10 ± 0.28 | 0.27 ± 0.09 |
| Bone | 0.81 ± 0.23 | 0.44 ± 0.12 | 1.14 ± 0.01 | 0.42 ± 0.16 | 0.83 ± 0.22 | 0.58 ± 0.42 | 0.87 ± 0.06 | 0.14 ± 0.02 |
| Tumor | 2.72 ± 0.63 | 0.86 ± 0.23c | 2.97 ± 0.58 | 0.99 ± 0.37 | 2.95 ± 0.40 | 1.46 ± 0.33 | 2.07 ± 0.23 g | 0.25 ± 0.03e,f,g |
| Tumor/Blood | 2.02 ± 0.51 | 1.73 ± 0.26c | 1.59 ± 0.28 | 1.98 ± 0.39d | 1.56 ± 0.15 | 3.96 ± 0.26 | 1.74 ± 0.35 | 1.17 ± 0.31e,f,g |
| Intestine* | 5.56 ± 0.77c | 5.88 ± 0.98c | 5.12 ± 1.23 | 7.89 ± 3.22d | 4.07 ± 0.25 | 2.60 ± 0.21 | 1.67 ± 0.49e,f,g | 0.85 ± 0.21f |
| Stomach* | 1.03 ± 0.20 | 0.88 ± 0.28c | 1.22 ± 0.62 | 0.65 ± 0.43 | 1.03 ± 0.52 | 0.19 ± 0.07 | 0.94 ± 0.36 | 0.61 ± 0.38 |
| Neck* | 0.09 ± 0.02 | 0.11 ± 0.03 | 0.03 ± 0.01 | 0.09 ± 0.03 | 0.02 ± 0.01 | 0.01 ± 0.00 | 0.35 ± 0.06e,f,g | 0.54 ± 0.11e,f,g |
aTissue radioactivity was expressed as %ID/g ± SD for each group (n = 5)
*Tissue radioactivity was expressed as %ID. Statistical analysis was performed using on-way ANOVA followed by Tukey’s test between [211At]At-NpGT and [125I]I-NpGT (b), [211At]At-NpGT and [18F]F-NpGT (c), [125I]I-NpGT and [18F]F-NpGT (d), [211At]At-NpGT and [125I]I-IMT (e), [125I]I-NpGT and [125I]-IMT (f), and [18F]F-NpGT and [125I]I-IMT (g)