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. 2024 Feb 26;15:1352. doi: 10.1038/s41467-024-45440-7

Fig. 4. Hdac6-KO mice exhibit slower progression of HFpEF, and do not respond to TYA-018 treatment.

Fig. 4

a Schematic overview of study design. Hdac6 knockout (KO) and wild-type (WT) mice treated with HFD + L-NAME for 16 weeks and then randomized to receive oral dosing of vehicle or TYA-018 (15 mg/kg) once per day for 8 weeks. Heart function was measured by echocardiography. Time course of (b) LVPWd, (c) IVRT (d) E/e’ ratio at 4, 8, 12, and 16 weeks after HFD + L-NAME induction. Quantitation of (e) LVPWd, (f) IVRT and (g) E/e’ ratio after 8 weeks of TYA-018 treatment. Mice number in each group is indicated in graphs. Data are expressed as the mean ± SEM. Statistical analysis was performed using two-way ANOVA (b–d) or one-way ANOVA followed by Tukey’s multiple comparisons test (e–g). The exact P values are shown in the figures. Source data are provided as a Source Data file.