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. 2024 Feb 26;15:1352. doi: 10.1038/s41467-024-45440-7

Fig. 6. HDAC6 inhibition by TYA-018 restores dysregulated fibrosis and metabolic transcripts in heart tissue from HFpEF mice.

Fig. 6

a Significantly altered gene sets from MSigDB canonical pathways. b Heatmap of differentially regulated genes associated with cardiac fibrosis as well as inflammatory and mitochondrial function in all groups (n = 8–11 mice per group). c Uniform manifold approximation and projection (UMAP) plot after single-nuclei RNA sequencing of left ventricular tissue. d UMAP plot of four cardiomyocytes (CM) subclusters. e UMAP plot of nine fibroblast (FB) subclusters. f Heatmap of the top 10 maker genes for each CM subclusters. g Heat map showing the expression of the top 5 maker genes for each FB subclusters. h Composition of the four CM subclusters within the four groups. i Gene ontology enrichment analysis of CM cluster 3. j Composition of the nine FB subclusters within the four groups. k Gene ontology enrichment analysis of FB cluster 6. ECM extracellular matrix; TCA tricarboxylic acid.