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. 2024 Feb 5;43(4):533–567. doi: 10.1038/s44318-024-00030-7

Figure 3. Phospholipid and FFA profile in 12mo mice.

Figure 3

Lipid response to instrumental conditioning across the brain of DDHD2 knockout (KO) and wild type (WT) animals. (A–H) Phospholipid responses (A–D) phospholipids containing C14:0, C16:0 and C18:0 acyl chains. (E–H) phospholipids not containing C14:0, C16:0 and C18:0 acyl chains. (I) Fold-change response of FFAs to instrumental conditioning at 12mo. (J, K) Average response of FFAs and phospholipids across all the brain regions in cohorts of DDHD2+/+ (WT) or DDHD2−/− (KO) mice: AM—central amygdala, CX—Cortex, VH—ventral hippocampus, DH—dorsal hippocampus, CB—cerebellum. Lipids: PA—phosphatidic acid, PC—phosphatidylcholine, PE—phosphatidylethanolamine, PG—phosphatidylglycerol, PS—phosphatidylserine. Dotted boxes show myristoyl-containing phospholipids decreasing in the dorsal hippocampus. Data information: In (A–I), each pixel in the heatmap represents the average change in total abundance of all lipids of a given class across the 6 measured brain regions (n = 6 biological replicates). In (J, K), each dot on the volcano plot represents the average change in abundance of a single lipid analyte across 5 measured brain regions in control vs instrumentally conditioned DDHD2+/+ vs DDHD2−/− mice. Analytes below the red line represent those whose change in abundance was not statistically significant (two-tailed t-test p  >  0.05). Source data are available online for this figure.