Skip to main content
. 2024 Feb 26;9:45. doi: 10.1038/s41541-024-00827-x

Fig. 4. Clinical outcomes post-challenge.

Fig. 4

a–d Mice, n = 8/group ½ female were challenged with 10^7 EID50/mouse of B/Bris PB2 F406Y virus at 3 weeks post-boost vaccination. Body weight changes and survival were recorded and graphed in Prism 9.3.1 as shown. Yellow symbols correspond to groups of challenged mice previously vaccinated with IGIP-containing FLUBV recombinants. Gray symbols correspond to challenged mice previously vaccinated with non-IGIP FLUBV recombinants whereas red symbols correspond to challenged mice previously mock-vaccinated. All IGIP and non-IGIP FLUBV vaccinated mice show complete protection, 100% survival and negligible clinical signs regardless of biological sex, unlike the mock-vaccinated challenged group.