Table 5.

Correlation of corrected odor identification scores (adjusted for age, sex, ApoE4, and MMSE) with CSF biomarker levels: Spearman's rho of studentized residuals.

CSF AD biomarkers	rho	P-value
A. Normal biomarkers and selected AD continuum group (A−/T−/N−, A+/T−/N−, A+/T+/N−, and A+/T+/N+)
Aβ40	− 0.013	0.911
Aβ42	0.230	0.043
Aβ42/40 ratio	0.292	0.010
p-Tau	− 0.097	0.400
t-Tau	− 0.183	0.109
p-Tau/Aβ42 ratio*	− 0.206	0.070
p-Tau/t-Tau ratio*	0.042	0.716
B. Normal biomarkers and p-Tau accumulation without amyloidogenesis group (A−/T−/N−, A−/T+/N−, and A−/T+/N+)
Aβ40	0.198	0.094
Aβ42	0.195	0.099
Aβ42/40 ratio	− 0.033	0.781
p-Tau	− 0.040	0.739
t-Tau	0.082	0.491
p-Tau/Aβ42 ratio	− 0.084	0.479
p-Tau/t-Tau ratio	− 0.034	0.774
C. Normal biomarkers and SNAP group (A−/T−/N−, A−/T+/N−, A−/T+/N+, and A−/T−/N+)
Aβ40	0.123	0.261
Aβ42	0.130	0.237
Aβ42/40 ratio	− 0.024	0.831
p-Tau	− 0.036	0.742
t-Tau	0.032	0.769
p-Tau/Aβ42 ratio	− 0.048	0.661
p-Tau/t-Tau ratio	− 0.041	0.712

Weak correlations were found between corrected odor identification scores and CSF biomarkers (Aβ42 and Aβ42/40 ratio) in the group characterized by normal biomarkers and selected AD continuum group (A).

No correlations were found between corrected scores for odor identification and CSF biomarkers (Aβ42 and Aβ42/40 ratio) in the group characterized by normal biomarkers and p-Tau accumulation without amyloidogenesis (B), as well as in the group characterized by normal biomarkers and SNAP (C).

CSF cerebrospinal fluid; AD Alzheimer’s disease; SNAP suspected non-AD pathophysiology.

Significant values are in [bold].

*Logarithmic transformation.