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. 2024 Feb 26;15(2):174. doi: 10.1038/s41419-024-06554-4

Fig. 2. miR-184-knockout enhances the susceptibility to chemical-induced skin carcinogenesis in mouse.

Fig. 2

A Schematic overview of two stage-carcinogenesis experiment applied for adult 2-month old wild type (WT) and miR-184-knockout (KO) mice. A single topical application of the carcinogen (DMBA) was followed by topical application of the tumor prompter (TPA) twice a week. B The average number of tumors per mouse of the indicated genotype across time. Twenty-weeks post DMBA induction, tumors were isolated and their average weight was calculated (C) and the back skin of pictured (D). E The relative expression of miR-184 in healthy back skin of wild type mice, not subjected to DMBA/TPA treatment (Healthy WT), versus murine tumor that developed in wild type mice (Tumor WT), indicates a decrease in miR-184 during tumorigenesis. Data represents average and standard deviation from 6 biological replicates. Scale bars were 20 μm. Statistical significance was assessed by t test (*p < 0.05).