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. 2024 Jan 15;43(3):391–413. doi: 10.1038/s44318-024-00027-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Cartoon schematic summarizing mitochondrial morphological observations dependent on Opa1 state. Mitochondria in l-Opa1* cells displayed WT-like CJ widths and perpendicularity. The majority of mitochondria displayed a stacking phenotype and multijunction cristae. Tubular and vesicular cristae were found in s-Opa1* cells. Summaries of functional dysfunctions corresponding to observed cristae morphological changes. (A) Respiratory defects correlate with a large number of unstructured cristae. (B) Defects in cytochrome c (CytC) release properties (as evaluated by BH3 profiling) and calcium handling correlate with wider CJ and vesicular cristae. (C) Cartoon scheme with hypothesized modes of action for l-Opa1 in the crista stacking. (D) Cartoon schematic with hypothesized modes of action for l-Opa1 in BH3 and calcium handling process.