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. 2024 Jan 22;25(2):524–543. doi: 10.1038/s44319-023-00028-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) KEGG enrichment scatterplot of significant pathway after d-malate treatment in vascular endothelial cell (n = 3 for each group). (B) Volcano plot of significant genes after d-malate treatment in vascular endothelial cell (n = 3 for each group). (C) The relationship between acetyl-CoA, PDE4D, SUZ12, BRD7, ACAT2, LMNA, and RUVBL2. (D) The relative acetyl-CoA content in vascular endothelial cell (n = 3 for each group). (E, F) The protein expression (E) and statistics (F) of Pan-Acetylation in vascular endothelial cell protein solution after d-malate treatment was detected by western blot (n = 4 for each group). (G, H) Immunoprecipitation (G) and statistics (H) of Ace-Cyclin A2 in vascular endothelial cell after d-malate treatment (n = 4 for each group). (I, J) Representative images (I) and statistics (J) of vascular endothelial cell tube formation test within C646 and d-malate treatment. (n = 2 for 1 μM C646 + d-malate group, n = 3 for other groups). Data information: t test was used in this figure where error bars represent SEM, and *P < 0.05; **P < 0.01. Source data are available online for this figure.