Figure 1.

Representative experimental timeline. 24-week-old male and female C57Bl/6J were cage acclimated at 14-days prior to irradiation (IR-14) and socially isolated at IR-4. At IR + 0, mice were irradiated with 5-ion GCRsim ionizing radiation at 15 and 50 cGy, along with a unirradiated sham controls that were exposed to similar housing restraints and time as IR mice (0 cGy). Retro-orbital blood collection was performed on IR + 3 and abdominal aorta blood and tissues were collected on the time of euthanasia, IR + 14.