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Individuals with PHTS and pre-SMN display more pronounced genome-wide cfDNA fragmentation
The median fragment ratio (defined as the ratio of short to long fragments) plotted in 5-Mb genomic bins for patients with PHTS stratified by SMN status and plasma draw time within the (A) mononucleosome, (B) dinucleosome, and (C) trinucleosome fractions (see also Table S3).
