Figure 4.

Individuals with PHTS and SMNs display distinct end motif profiles

(A) Heatmap displaying Z score transformed of the significantly differentially abundant 4-mer motif frequencies. The color gradient reflects the number of SDs from the mean frequency. Darker shades indicate lower relative abundance, whereas lighter shades suggest higher relative abundance. (B and C) Boxplot of the 2-mer and 1-mer motif frequencies stratified by SMN status. (D and E) Boxplot of 2-mer and 1-mer end motif frequencies stratified by SMN status and plasma draw time. Motif frequencies are relative to the total number of end motifs across all of the nucleosome fractions. The center line in each boxplot represents the median. Each box extends from the 25th to the 75th percentile (IQR) (see also Table S4).