Table 2.
Multivariable logistic regression: Elevated mono- and dinucleosome cfDNA fragments associated with SMN diagnosis
| Variables | Model 1 |
Model 2 |
Model 3 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | |
| Age at draw | 1.08 | 1.03–1.15 | 0.001 | 1.08 | 1.03–1.15 | <0.001 | 1.08 | 1.03–1.14 | <0.001 |
| CC score | 1.01 | 0.96–1.05 | 0.8 | 1.00 | 0.95–1.05 | >0.9 | 1.0 | 0.95–1.04 | 0.8 |
| Ratio1 | 2.37 | 1.09–7.27 | 0.025 | – | – | – | – | – | – |
| Ratio2 | – | – | – | 3.03 | 1.07–15.7 | 0.029 | – | – | – |
| Ratio3 | – | – | – | – | – | – | 1.40 | 0.96–2.10 | 0.078 |
CC, Cleveland Clinic; CI, confidence interval; OR, odds ratio; ratio1, mononucleosome-associated fragment ratios; ratio2, dinucleosome-associated fragment ratios; ratio3, trinucleosome-associated fragment ratios.