REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Plasma samples from patients with PHTS with and without cancer	Genomic Medicine Biorepository, Cleveland Clinic	N/A
Critical commercial assays
QIAamp Circulating Nucleic Acid Kit	QIAGEN	Cat #55114
NEBNext Ultra DNA Library Prep Kit for Illumina	New England BioLabs	Cat #E7370L
cfDNA extraction and Ultra-low pass WGS	Broad Institute	http://genomics.broadinstitute.org/products/liquid-biopsy-sequencing
Deposited data
De-identified cfDNA fragment files	This paper	https://doi.org/10.5281/zenodo.8422534
Software and algorithms
R (v.4.2.3)	CRAN	https://www.r-project.org/; RRID: SCR_003005
R Studio	Posit	https://posit.co/products/open-source/rstudio/; RRID: SCR_000432
Original code	This paper	https://doi.org/10.5281/zenodo.10372575
SAMtools (v.1.16.1)	Danecek et al.39	http://www.htslib.org/; RRID: SCR_002105
BEDtools (v.2.29.0)	Quinlan and Hall40	https://bedtools.readthedocs.io/en/latest/content/installation.html; RRID: SCR_006646
ggplot2 (v.3.4.1)	Wickham et al.41	https://ggplot2.tidyverse.org/; RRID: SCR_014601
pROC (1.18.4)	Robin et al.42	https://cran.r-project.org/web/packages/pROC/index.html; RRID:SCR_001905
pheatmap (v.1.0.2)	Kolde43	https://cran.r-project.org/web/packages/pheatmap/index.html; RRID: SCR_016418
Other
ENCODE Blacklist Regions	Amemiya et al.44	https://github.com/Boyle-Lab/Blacklist/