Figure 2.
Scatterplots of gene expression regulations and SNP associations of LVEF and HF in males and females
(A) The relationship of genetic effects of eQTLs between males and females.
(B) SNP associations of LVEF between males and females.
(C) SNP associations of HF between males and females.
The x axis represents estimates in males and the y axis represents estimates in females. The gray smoothing lines and shaded regions around them represent the overall trend and 95% confidence intervals (CIs) of the estimates. Ρ calculated by Spearman correlation methods were used to quantify the correlations. Only cis-eQTLs that are closely associated with genes (with p < 1.0 × 10−5) and have sufficient power (F-statistics ≥10) were included in MR analyses and depicted.