Figure 3.
Manhattan plot of sex-stratified genome-wide LVEF associations
Sex-stratified GWAS was conducted using the BOLT-LMM method (n = 17,899 in males, n = 19,467 in females). The x axis represents the genomic position and the y axis represents the strength of association as represented by −log10 (p value). Suggestive associations at a significance level of p < 1 × 10−5 are indicated by the black line and genome-wide significance at p < 5 × 10−8 is indicated by the red line. Independent genome-wide significant variants are annotated with the nearest gene(s). Male-specific candidate genes are denoted by blue boxes, female-specific candidate genes are denoted by red boxes, and candidate genes found in both sexes are denoted by green boxes.